Nicola Zagame made her debut for Australia in the 2009 FINA World League. She competed at the 2010 World Cup and was key to Australia knocking off Russia in the semi finals, scoring 3 goals in the 11-10 victory, before Australia went on to claim silver. Zagame won bronze at the 2011 World League Finals, before starring at the 2012 Pan Pacific Championships where Australia went through undefeated to claim the gold. Zagame scored two goals at the London Test Event to help Australia to a 6-5 victory over their American rivals.
Zagame’s strong form in front of goal was rewarded with selection in the Australian squad for the London 2012 Games where she made her Olympic debut. After topping their group in the preliminary round the Australians played extra time games in the quarter-final, semi-final and bronze medal decider. They defeated China in a penalty shoot-out before falling to their American rivals in the semi 11-9. In the bronze medal showdown Hungary scored in the final second to force an extra period. The Australians remained composed and scored the only two goals in added time to take home the bronze medal, 13-11.